The poor prognostic factor associated with ALL in children is
Correct Answer: Testicular involvement
Description: The standard features are age and WBC at diagnosis, with infants (less than one year), adolescents (greater than nine years), and children with WBC above 50,000/ml being at higher risk. Ceain chromosomal abnormalities are also strong predictors; in paicular, the Philadelphia chromosome and MLL gene rearrangements (especially in infants) are adverse features, while TEL-AML1 is orable. It is impoant to note, however, that even the most impoant known predictors explain only a small propoion of the variability in outcome. Testicular involvement Is a poor prognostic factor for ALL Reference: GHAI Essential pediatrics, 8th edition
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