Receptor responsible for malignant hyperthermia is?
Correct Answer: Ryanodine receptor
Description: ANSWER: (B) Ryanodine receptorREF: Morgan 3ra e p. 869This condition is known by a number of names, including malignant hyperthermia (MH), malignant hyperthermia syndrome (MHS), and malignant hyperpyrexia.Signs and symptoms:The typical symptoms of malignant hyperthermia are due to a hyper catabolic state, which presents as a very high temperature, an increased heart rate and breathing rate, increased carbon dioxide production, increased oxygen consumption, acidosis, rigid muscles, and rhabdomyolysis.The symptoms usually develop within one hour after exposure to trigger substances, but may even occur several hours later in rare instances.Causes:Volatile anesthetic gases Local anesthetics Depolarizing muscle 1 relaxantshalothane, sevoflurane, desfluranelidocaine, bupivicaine, mepivacainesuccinylcholineOtherOpiates (morphine, fentanyl), ketamine, barbiturates, nitrous oxide, propofol, etomidate, benzodiazepinesGenetics:Malignant hyperthermias inheritance is autosomal dominant. The defect is typically located on the long arm of the nineteenth chromosome (19ql3.1) involving the ryanodine receptor.
Category:
Anaesthesia
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now