Which of the following statements about fluconazole is most accurate?

A. It is highly effective in the treatment of aspergillosis

B. It does not penetrate the blood-brain barrier

C. Its oral bioavailability is less than that of ketoconazole

D. It inhibits demethylation of lanosterol

Correct Answer: It inhibits demethylation of lanosterol

Description: * Fluconazole (Azoles) act by inhibiting the enzyme lanosterol-14-a-demethylase resulting in reduced ergosterol synthesis. * It has very good CNS penetration and oral bioavailability. * It is not very effective against aspergillosis (voriconazole is the drug of choice).

Category: Pharmacology

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