Which of the following is false regarding transfusion associated anaphylactic reactions?
Correct Answer: Seen in IgG deficient individuals
Description: Ref: Aled scape/ Transfusion reactionsExplanation:Allergic transfusion reactions occur on a continuum of severity ranging from mild (urticarial) to moderate (anaphylactoid) to severe (anaphylactic). Anaphylactic transfusion reactions are severe allergic reactions characterized by profound hypotension and shock.Causes of anaphylaxis include:Recipient IgE or IgG antibodies to IgA in patients who have complete or partial (i.e., lack an isotopic or allotypic) IgA determinantRecipient IgE or IgG antibodies to polymorphic forms of other serum proteins (IgG. haptoglobin. C4, etc.) in transfused donor bloodRecipient sensitization to various compounds, including drugs in donor blood, chemicals used to produce or sterilize IV tubing and plastic bags, and foodstuffsCoincidental reaction to drugs or food taken prior to transfusionIg A deficiencyIn patients with IgA deficiency --Anti-IgA antibodies may develop after exposure to IgA in transfusions: anaphylactic reactions to IV immune globulin (IVIG) and other blood products that contain IgA may occur.Washed blood product can reduce the incidence of Anaphylaxis
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