A child few hours after ingestion of a fruit, vomiting started later developed convulsion. In the hospital his blood glucose was very low, but no ketone bodies. The fruit he ingested was identified as a fruit found in Africa. What is the diagnosis?
Correct Answer: Jamaican vomiting sickness
Description: Ans. D. Jamaican vomiting sickness* The fruit given in picture is Ackee apple fruit seen in Africa.* The fruit contains a toxin hypoglycin that inhibit acyl-CoA dehydrogenase.* Lack of beta oxidation results in lack of ATP and acetyl-Co A, which decreases gluconeogenesis.* This result in hypoglycaemia.* No ketone bodies due to lack of beta oxidation.
Category:
Biochemistry
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