Integrin connects actin to which macromolecule in ECM:
Correct Answer: Laminin
Description: CAMs bind to laminins, a family of large cross-shaped molecules with multiple receptor domains in the extracellular matrix. Laminin is a high molecular weight ECM protein. Many CAMs pass through the cell membrane and are anchored to the cytoskeleton inside the cell. Some bind to like molecules on other cells (homophilic binding), whereas others bind to nonself molecules (heterophilic binding). Actin is connected to the sarcolemma, from where integrin connects it to laminin in ECM.
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