If carbamazepine is added to valproate, which side effect of valproate can increase?
Correct Answer: Hepatotoxicity
Description: Valproate is metabolized by cytochrome P450 and produce a metabolite which is hepatotoxic Carbamazepine is enzyme inducer which cause the induction of its metabolism and produce more metabolite, thus causing hepatotoxicity
Category:
Pharmacology
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