Long-term tamoxifen therapy may cause:

Correct Answer: Endometrium Ca
Description: Long-term tamoxifen therapy is a predisposing factor for endometrial hyperplasia and cancers. Malignancies caused by Long-term tamoxifen therapy: Carcinoma endometrium-it is the most common carcinoma associated with it. Uterine sarcoma. Rarely liver cancer with a long-term high dose. Non-malignant effects of tamoxifen on uterus: Endometrial hyperplasia Endometriosis Fibroid uterus Ovarian cysts Menstrual irregularities or amenorrhea.
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