Complement level is reduced in:
Correct Answer: Membrane proliferative GN
Description: Ans. D. Membrane proliferative GNMembranoproliferative GlomerulonephritisCauses of Membranoproliferative Glomerulonephritis1. Type I Disease (Most Common)a. Idiopathicb. SLEc. Endocarditisd. Hepatitis Ce. Hepatitis Bf. Mixed cryoglobulinemiag. Cancer: Lung, breast, and ovary (germinal)2. Type II Disease (Dense Deposit Disease)a. Idiopathicb. C3 nephritic factor-associatedc. Partial lipodystrophy3. Type III Diseasea. Idiopathicb. Complement receptor deficiencyClinical Featurea. They present with microscopic to gross hematuria and selective or non - selective proteinuria depending on the severity of the disease.b. They have a poor prognosis, developing renal failure 5-10 years after diagnosis.c. Complement level is reduced
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