Kallmans syndrome is associated with all of the following except
Correct Answer: Excess stimulation of the HPO axis
Description: When congenital GnRH deficiency is associated with anosmia or hyposmia (an absent or grossly impaired sense of smell), the disorder is known as Kallmann&;s syndrome. Two genetic mutations associated with Kallman&;s Syndrome : KAL gene - X - linked inheritance (Xp22.3) encoding anosmin - 1. Gene encoding FGFR1 (Fibroblast growth factor - 1 receptor) - autosomal dominant form. Anosmin - 1 is a neural adhesion molecule that promotes migration of GnRH neurons and olfactory neurons, from the olfactory placode into the hypothalamus during embryonic development. REF : Shaw book of gynecology 9th Ed.
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Gynaecology & Obstetrics
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