Primary’ hyperaldosteronism doesn’t lead to –
Correct Answer: Hyperkalemia
Description: Ans. is 'a' i.e., Hyperkalemia Clinical manifestations of hvperaldosteronismo Excess activation of the mineralocorticoid receptor leads to potassium depletion and increased sodium retention, with the latter causing an expansion of extracellular and plasma volume,o Increased ENaC activity also results in hydrogen depletion that can cause metabolic alkalosis,o Aldosterone also has direct effects on the vascular system, where it increases cardiac remodeling and decreases compliance. Aldosterone excess may cause direct damage to the myocardium and the kidney glomeruli, in addition to secondary damage due to systemic hypertension,o Hypokalemia can be exacerbated by thiazide drug treatment, which leads to increased delivery of sodium to the distal renal tubule, thereby driving potassium excretion.o Severe hypokalemia can be associated with muscle weakness, overt proximal myopathy, or even hypokalemic paralysis. Severe alkalosis contributes to muscle cramps and, in severe cases, can cause tetany.
Category:
Pathology
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