All are true statements regarding Lemborexant except :
Correct Answer: It is an orexin receptor agonist
Description: Lemborexant FDA approved drug for the treatment of insomnia which got its approval after two Phase III clinical trials namely SUNRISE I and SUNRISE II. Useful in insomnia ,characterized by difficulties with sleep onset and/or sleep maintenance. Orexin neuropeptide signaling system plays a role in wakefulness. Blocking the binding of wake-promoting neuropeptides orexin A and orexin B to orexin receptors OX1R and OX2R is thought to suppress wake drive. Lemborexant binds to orexin receptors OX1R and OX2R and acts as a competitive antagonist with stronger inhibition effect to OX2R most common adverse effect is somnolence
Category:
Pharmacology
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