Deficiency of GpIIb-IIIa results in which of the following condition?
Correct Answer: Glanzmann thrombasthenia
Description: Platelet activation by ADP triggers a conformational change in the platelet GpIIb-IIIa receptors that induces binding to fibrinogen, a large protein that forms bridging interactions between platelets that promote platelet aggregation. Predictably, inherited deficiency of GpIIb-IIIa results in a bleeding disorder (Glanzmann thrombasthenia). Ref: Robbins 8th edition Chapter 4.
Category:
Pathology
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