Furosemide mechanism of action in LVF is: September 2010
Correct Answer: Inhibitor of Na-K-Cl ion sympo
Description: Ans. A: Inhibitor of Na-K-Cl ion sympo Like other loop diuretics, furosemide acts by inhibiting the Na-K-2C1 sympoer in the thick ascending limb of the loop of Henle. The action on the distal tubules is independent of any inhibitory effect on carbonic anhydrase or aldosterone; it also abolishes the coicomedullary osmotic gradient and blocks negative as well as positive free water clearance.
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