Which gene is involved in pathogenesis of Type 1 Diabetes mellitus?
Correct Answer: CTLA-4
Description: Polymorphism in promoter region of insulin gene, CTLA-4 contributes to susceptibility to type 1 Diabetes mellitus. The most common cause of type 1 diabetes mellitus is autoimmunity. Most patients have DR3 and/ or DR4 haplotype.
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