Person had severe pruritis while taking hot shower and presents with deep vein thrombosis. He also had JAK 2 mutation and hypeension. Which of the following is the most likely diagnosis of this patient?
Correct Answer: Polycythemia Vera
Description: The presence of JAK2 mutation indicates that it is an example of Myeloproliferative disorder. Polycythemia vera is strongly associated with activating point mutations in the tyrosine kinase JAK2. Clinical features: Headache, dizziness, hypeension,Intense pruritus and peptic ulceration possibly resulting from the release of histamine from basophils. Hot showers ( AQUAGENIC PRURITUS ) will result in degranulation of the basophils thus releasing histamines.
Category:
Pathology
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