Gastrointestinal stromal malignancy arises from which of the following –
Correct Answer: Interstitial cells of Cajal
Description: "Gastrointestinal stromal tumors (GIST) originate from the interstitial cells of Cajal, which controls gastrointestinal peristalsis."
On rare occasions, gastric GISTs occur as part of tumor - syndrome, such as :-
Carney's trads → Gastric GIST, Paraganglioma and pulmonary chondroma.
Neurofibromatosis Type I
Histologically, GISTs can be divided into
Spindle types → Exhibit spindle cells
Epithelioid types → Exhibit epithelioid cells
Mixed types → A mixture of both
Category:
Pathology
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