During the asymptomatic latent phase of AIDS, the virus is actively proliferating, and can be found in association with?
Correct Answer: Follicular dendritic cells in lymph nodes
Description: Follicular dendritic cells in the germinal centers of lymph nodes are impoant reservoirs of HIV. Although some follicular dendritic cells are infected with HIV, most viral paicles are found on the surface of their dendritic processes. Follicular dendritic cells have receptors to the Fc poion of immunoglobulins that serve to trap HIV virions coated with anti-HIV antibodies. These coated HIV paicles retain the ability to infect CD4+ T cells as they traverse the dendritic cells. B lymphocytes have a surface marker (CD21 protein-a complement receptor) to which an Epstein-Barr envelope glycoprotein can bind. The virus associates with the host cell genome, producing a latent infection. These B cells undergo polyclonal activation and proliferation. Ganglion cells, paicularly the satellite cells around the ganglion cells in the dorsal root ganglia, can be infected by varicella-zoster. Herpes type I and II infect neurons that innervate skin and mucous membranes. Oligodendrocytes are directly infected by two viruses, JC virus (a polyomavirus) and measles virus. JC virus causes progressive multifocal leukoencephalopathy (PML), and measles virus produces a latent syndrome called subacute sclerosing panencephalitis (SSPE). Ref: Levinson W. (2012). Chapter 58. Cellular Basis of the Immune Response. In W. Levinson (Ed), Review of Medical Microbiology & Immunology, 12e.
Category:
Microbiology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now