Which of the following is a prodrug is –
Correct Answer: Primidone
Description: (C) (Primidone) (38 - H 18th) (23, 413 - KDT 7th)PRIMIDONE - A deoxybarbiturate converted by liver to phenobarbitone and phenylethyl malonamide (PEMA). Its antiepileptic activity is mainly due to those active metabolites because t 1/2 of primidone (6-14 hr.) is less than that of its active metabolites, About 1/3 primidone is excreted unchanged by Kidney.Prodrugs are inactive compounds that require metabolism to generate active metabolites that mediate the drug effects. Examples include many angiotensin-converting enzyme (ACE) inhibitors, the angiotensin receptor blocker losartan, the antineoplastic irinotecan, the anti-estrogen tamoxifen, the analgesic codeine (whose active metabolite morphine probably underlies the opioid effect during codeine administration), and the antiplatelet drug clopidogrel. Drug metabolism has also been implicated in bioactivation of procarcinogens and in generation of reactive metabolites that mediate certain adverse drug effects (e.g., acetaminophen hepatotoxicity).ProdrugActive formLevodopa- DopamineEnalapril- Enalaprilata-Methyldopa- a-methylnorepinephrineDipivefrine- EpinephrineSulindac- Sulfide metaboliteProguanil- CycloguanilPrednisone- PrednisoloneBacampicillin- AmpicillinSulfasalazine- 5-Aminosalicylic acidCyclophosphamideAidophosphamide, phosphoramide mustard, acroleinFluorouracil- Fluorouridine monophosphateMercaptopurine- Methylmercaptopurine ribonucleotideAcyclovir- Acyclovir triphosphate
Category:
Pharmacology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now