All are true about sulphonyl ureas except?

A. It blocks ATP sensitive K+ channels and increase insulin release

B. They have higher risk of causing hypoglycemia than meglitinides

C. They are used mainly in type 1 DM

D. Chlorpropamide can cause dilutional hyponatremia

Correct Answer: They are used mainly in type 1 DM

Description: Sulphonyl ureas are mainly used in Type 2 DM because Type 1 DM is characterized by autoimmune destruction of β - cells of pancreas and atleast 30% of β - cells should be present for sulphonyl ureas to be effective.

Category: Pharmacology

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