Nevirapine is –
Correct Answer: NNRTI
Description: Ans is 'b' i.e., NNRTI o Nevirapine is NNRTIThese drugs inhibit reverse transcriptase by acting at a site (allosteric site) different from NRTIs.These are selective for HIV-1 and have no activity against HIV-2.Resistance to these drugs develops very rapidly.o NNRI drug groupEfavirenz, nevirapine, etravirtue and delavirdine,o Mechanism of action :These are nucleotide unrelated compounds which directly inhibit HIV reverse transcriptase without the need for intracellular phosphory-lation.Adverse effectsRashes (Steven Johnson Syndrome & Toxic epidermal necrolysis)NauseaHeadach, FeverRise in live enzyme (hepatotoxic)o Nevirapine is used in pregnancy to prevent vertical transmission.o It decrease transmission to 13% as compared to 21.5% by zidovudine.o NNRTI donot cause lipodystrophy like NRTIs and RTIs# Nevirapine and efavirenz are enzyme inducers and delaviridine is enzyme inhibitor.
Category:
Pharmacology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now