Which of the following opioid should not be used with MAO inhibitors?
Correct Answer: Pethidine
Description: Ref: KD Tripathi 6/e p440 Most of Pethidine is metabolized by MAO-A and is inactivated. Small amount is conveed to nor-Pethidine, which has CNS stimulant propeies. Therefore if combined with MAO inhibitors, most of Pethidine will form nor-Pethidine and the risk of seizures will increase.
Category:
Pharmacology
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