Which of the following statements is true of hereditary spherocytosis (HS)?

A. Pigment-type of gall stones are common

B. Diagnosis can be made in neonatal period easily by examination of a blood film

C. Intravascular hemolysis is a common feature

D. Autosomal recessive inheritance in majority of the cases

Correct Answer: Pigment-type of gall stones are common

Description: Discussing the options about HS - a. TRUE D/t chronic hemolysis, pigmented stones are formed in gall bladder. b. FALSE In newborns, Spherocytosis & reticulocytosis are frequently minimal or absent c FALSE Hemolysis in hereditary spherocytosis is mainly extravascular d. FALSE 75% cases of HS have autosomal dominant inheritance Anisocytosis and several hyperchromic spherocytes are seen. Howell-Jolly bodies can be seen.

Category: Pathology

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