All are true about follicular lymphoma except:
Correct Answer: CD 5+
Description: Ans. is 'b' i.e.CD 5+ Follicular lymphoma o Follicular lymphoma is the most common form of indolent non-Hodgkin's lymphomas and the second most common form of non-Hodgkin's lymphoma overall. o It is the tumor of germinal center (follicular center), B cells, and is strongly associated with chromosomal translocation involving Bcl 2 o Growth pattern is nodular (follicular) or nodular (follicular) and diffuse. o Two principal cell types are present in varying propoion: (i) Small cleared cells (centrocytes) (ii) Centroblasts o In most follicular lymphomas, centrocytes predominate. Immunophenotype The neoplastic cells closely resemble normal germinal center B cells, expressing CD19, CD 20, CD 10, surface Ig, and Bel 6. o Unlike CLL/SLL and mantel cell lymphoma, CD 5 is not expressed. o Bcl 2 is expressed in more than 90% of cases, in distinction to normal follicular center B cells, which are Bcl 2 negative, and mantel cell lymphoma cells which express BCL 1 (cyclin D1). Molecular pathogenesis o The hallmark of follicular lymphoma is (14:18) translocation that juxtaposes the IgH locus on chromosome 14 and the Bel 2 locus on chromosome 18. Bcl 2 antagonizes the apoptosis and promotes the survival of follicular lymphoma cells --> while normal germinal centers contain numerous B cells undergoing apoptosis, follicular lymphoma is characteristically devoid of apoptotic cells
Category:
Pathology
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