Which NSAID undergoes enterohepatic circulation?
Correct Answer: Piroxicam
Description: Piroxicam: It is a long-acting potent NSAID with anti-inflammatory potency similar to indomethacin and good analgesic-antipyretic action. It is a reversible inhibitor of COX; lowers PG concentration in synol fluid and inhibits platelet aggregation-prolonging bleeding time. In addition, it decreases the production of IgM rheumatoid factor and leukocyte chemotaxis. Pharmacokinetics: 99% plasma protein bound; Excreted in urine and bile; enterohepatic cycling occurs Adverse effects: The g.i. side effects are more than ibuprofen, but it is better tolerated and less ulcerogenic than indomethacin or phenylbutazone; causes less fecal blood loss than aspirin. Rashes and pruritus are seen in < 1% of patients. Edema and reversible azotemia have been observed. ESSENTIALS OF MEDICAL PHARMACOLOGY;7TH EDITION; KD TRIPATHI; PAGE NO 201
Category:
Pharmacology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now