Regarding PCOS and hyperinsulinaemia

A. Hyperinsulinaemia is observed in about 40% to 80% of women with PCOS

B. Metformin has many other health benefits

C. Metformin causes hypoglycaemia in normoglycaemic women

D. Hyperinsulinaemia stimulates hepatic synthesis of SHBG

Correct Answer: Metformin has many other health benefits

Description: In PCOS Hyperinsulinemia is seen in 50-70% cases of PCOS Insulin induces LH to cause thecal hyperplasia and secrete androgens Hyperandrogenism lowers the level of hepatic sex hormone binding globulin Metformin treats the root causes, rectifies endocrine and metabolic function, improves fertility rate, used as insulin sensitiser It reduces insulin level, delays glucose absorption, liver production of glucose and improves peripheral resistance Metformin do not cause hypoglycemia in a normoglycemic women

Category: Gynaecology & Obstetrics

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