The given lesion is best associated with
Correct Answer: Atherosclerotic (ischemie) stroke
Description: Pale infarctions in the CNS best characterize the lesions associated with an atherosclerotic (ischemic) stroke. The four major causes of a cerebrovascular accident, or stroke, in order of frequency, are ischemia (60% to 90% of cases), intracerebral hemorrhage (e.g., hypeensive bleed), subarachnoid hemorrhage (e.g., ruptured berry aneurysm, aeriovenous malformation), and embolic infarction (e.g., hemorrhagic infarction). As a general rule, ischemic strokes are pale (80% of cases) and the other three are hemorrhagic. The majority of ischemic strokes are due to atherosclerosis. Atherosclerotic infarctions are most commonly secondary to a thrombus overlying an atheromatous plaque at the origin of the internal carotid aery. Consequences of atherosclerosis involving the cerebral vessels include cerebral infarction, cerebral atrophy, ischemic encephalopathy (laminar necrosis, watershed infarcts), transient ischemic attacks, and thromboembolism of a poion of atherosclerotic plaque to a distant location. They are usually pale infarcts because the atherosclerotic plaque occludes most of the lumen and reperfusion of the infarcted area usually does not occur. Grossly, there is softening of the brain after 6 hours, with a visible loss of normal demarcation between the gray and white matter. Microscopically, "red neurons" (i.e., apoptosis of individual neurons), nuclear pyknosis, and degeneration of myelin are present. After 2 to 10 days, the brain tissue is gelatinous. Neutrophils transiently invade the necrotic area but are soon replaced by microglial cells, many of which have engulfed lipid and appear as gitter cells. From 10 days to 3 weeks, liquefactive necrosis produces cystic areas in the brain. The subjacent brain parenchyma contains reactive astrocytes with eosinophilic cytoplasm. Cerebral infarcts present with a gradual onset of symptoms (i.e., transient ischemic attacks; TIAs), followed by localizing neurologic signs of contra lateral hemiplegia, aphasia, and visual defects (amaurosis fugax), depending on the site of infarction and whether the dominant hemisphere is involved. The majority of patients recover and regain paial restoration of their initial deficits. TIAs occur in patients with fixed atherosclerotic disease and are often caused by dislodgment of platelet and/or cholesterol emboli into the peripheral vessels. They generally last a few seconds to a few minutes and, by definition, recovery is within 24 hours. Unilateral symptoms suggest carotid ischemia, whereas bilateral symptoms suggest veebrobasilar ischemia, especially if accompanied by veigo, dysahria, or dysphagia. Ticlopidine, which inhibits the synthesis of adenosine diphosphate, or aspirin, which decreases the synthesis of thromboxane A2, are commonly used to prevent TIAs.
Category:
Radiology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now