Pick the false statement about pattern recognition receptors out of the following:
Correct Answer: NOD-like receptors (NLRs) are cytosolic receptors whose mutations lead to autoimmune disorders
Description: The best known of the pattern recognition receptors are the Toll-like receptors (TLRs). The TLRs are present in the plasma membrane and endosomal vesicles. Act by activation of:- NF-kB Interferon regulatory factors (IRFs) -NOD-like receptors (NLRs) are cytosolic receptors. They recognize products of necrotic cells, ion disturbances, and some microbial products. Several of the NLRs signal a cytosolic multiprotein complex called the inflammasome, which activates an enzyme (caspase-1) that cleaves a precursor form of the cytokine interleukin-1 (IL-1) to generate the biologically active form. IL-1 recruits leukocytes and induces fever. Gain-of-function mutations in one of the NLRs result in periodic fever syndromes, called autoinflammatory syndromes.
Category:
Pathology
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