Commonest mutations that are associated with GIST are in
Correct Answer: Tyrosine kinase KIT
Description: Approximately 75% to 80% of all GISTs have oncogenic, gain-of-function mutations in the receptor tyrosine kinase KIT. (C-KIT or CD 117)Approximately 8% of GISTs have mutations that activate a closely related receptor tyrosine kinase, platelet-derived growth factor receptor a (PDGFRA).Some GISTs without mutated KIT or PDGFRA have mutations in other genes that function in these pathways (NF1, BRAF, HRAS, or NRAS).Ref: Robbins Pathology; 9th edition; Page no: 775
Category:
Pathology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now