LD 50/ ED 50 is ?
Correct Answer: Therapeutic index
Description: Ans. is 'a' i.e., Therapeutic index Therapeutic index Drugs usually have more than one action. The maximal response for different action of a drug may be different ie the DRCs (Dose response curves) for different effects of a drug may be different. The extent of separation of DRCs of a drug for different effects is a measure of its selectivity, e.g. the DRCs for bronchodilatation and cardiac stimulation are quite similar in case of isoprenaline but far apa in case of salbutamol - the latter is more selective. The gap between the therapeutic effect DRC and the adverse effect DRC defines the safety margin or the therapeutic index.
Category:
Pharmacology
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