Mediator of acute inflammation not derived from the cell is (D. REPEAT Feb 2014)
Correct Answer: Kinins
Description: Chemical Mediators of Inflammation
Aka permeability factors or endogenous mediators of increased vascular permeability.
They are broadly classified into 2 groups:
i. Mediators released by cells.
ii. Mediators originating from plasma.
Chemical Mediators of Acute Inflammation
A. Cell-Derived Mediators
1. Vasoactive amines
Histamine
5-hydroxytryptamine
Neuropeptides
2. Arachidonic acid metabolites (Eicosanoids)
i. Metabolites via cyclo-oxygenase pathway
Prostaglandins
Thromboxane A2
Prostacyclin
Resolvins
ii. Metabolites via lipo-oxygenase pathway
5-HETE
Leukotrienes
Lipoxins
3. Lysosomal components (from PM Ns, macrophages)
4. Platelet-activating factor (PAF)
5. Cytokines
IL-1
TNF-α
TNF-β
IFN-γ
Chemokines
6. Free radicals
Oxygen metabolites
Nitric oxide
B. Plasma-Derived Mediators (Plasma Proteases) Products of:
1. The Kinin system.
2. The Clotting system.
3. The Fibrinolytic system.
4. The Complement system.
Category:
Pathology
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