The commonest mode of inheritance of congenital hea disease is
Correct Answer: Multifactorial
Description: Ref Harrison 19 th ed pg 1516 The most common bih defects are cardiovascular in origin. These malformations are due to complex multifactorial genetic and environ- mental causes. Recognized chromosomal aberrations and mutations of single genes account for <10% of all cardiac malformations. Congenital hea disease (CHD) complicates ~1% of all live bihs in the general population--about 40,000 bihs/year--but occurs more frequently in the offspring (about 4-10%, depending on maternal CHD type) of women with CHD. Owing to the remarkable surgical advances over the last 60 years, >90% of afflicted neonates and children now reach adulthood; women with CHD may now frequently successfully bear children after competent repairs.
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Anatomy
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