35 year old female patient complains of dry mouth and scratchy feeling in eyes. She is found to have antibodies against anti- SSA/Ro. Which of the following can be the most accurate sole criterion to diagnose the condition
Correct Answer: Lip tissue biopsy
Description: When Sjogren's syndrome is suspected, the most accurate sole criterion for diagnosis of the salivary component of this disorder is labial minor salivary gland biopsy. Antinuclear antibodies, rheumatoid factors, I e_evaied immunoglobulins (particularly immunoglobulin G ilg(iD, and erythrocyte sedimentation rate, serum amylase or the presence of antibodies directed against the more specific extractable nuclear antigens SS-A/Ro or SS-13/1.a are nonspecific markers of autoimmunity, but are important contributors to the definitive diagnosis of Sjogren's syndrome. lig, 60% patients will have antibodies against anti-SSA/Ro. This autoantibody is considered the most specific marker for Sjogren's syndrome although it may be found in a small percentage of patientsj
with systemic Iupus crythematosus or other autoimmune connective-tissue disorders.
Though there are no universally accepted diagnostic criteria for SS.
The strictest criteria include objective measurement of decreased salivary and lacrimal gland function, positive autoimmune serologies and a minor salivary gland biopsy specimen that demonstrates focal mononuclear cell infiltration in a periductal pattern (focus score>1).
Category:
Pathology
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