A peptic ulcer is associated with all except one –
Correct Answer: Pernicious anemia
Description: You, don’t expect pernicious anemia to cause peptic ulcer. In pernicious anemia, there is autoimmune destruction of the parietal cells leading to hypochlorhydria which further progresses to achlorhydria
Etiology. of peptic ulcer
Acute Peptic Ulcer
NSAIDS Ingestion
Stress
Cushing ulcer after cerebral trauma
Curling ulcer* after burn injury, any kind of shock
Sepsis — Undrained pus may be responsible for an acute ulcer.
Steroids
Chronic Gastric Ulcer
NSAIDs Ingestion
NSAIDs disrupt the prostaglandin driven support of the mucosal barrier.
Prostaglandins are responsible for the prodn. of mucosal gel layer in the stomach, which provide a protective barrier to the gastric and duodenal lining.
So disruption of this mucosal barrier allows even minimum amount of acid to cause ulceration.
Helicobacter pylori
H.Pylori is seen in almost 90% of cases of duodenal ulcer and 70% of cases of gastric ulcer.
Pyloroduodenal reflux
Regurgitate bile & other duodenal juices.
Mucosal trauma
by mechanical effect of food.
Diet & smoking
Irregular diet, spicy food excessive drinking of tea & coffee, alcohol, Cigarette smoking has a definite relation with both gastric & duodenal ulcers.
Emotional factors
Anxiety, Stress & strain.
Liver disease
Ulceration of both stomach and duodenum have co-existed with the disease of the liver, particularly cirrhosis.
It may be due to increase in blood supply to the gastric mucosa and overproduction of histamine in the stomach wall to stimulate the parietal cell.
Chronic Duodenal Ulcer
Acid hypersecretion
Genetic factors
Persons of blood group 'O' who do not possess AB antigen are peculiarly apt to develop a duodenal ulcer.
iii.Endocrinal disorders
Zollinger Ellison syndrome
Hyperparathyroidism
Multiple adenoma syndromes (MEN-I)
Cushing. syndrome (b/c of the high level of endogenous steroids)
Chronic liver diseases
Chronic lung disease
Chronic pancreatitis
Emotional factor
Diet & smoking
H.pylori
The decrease in bicarbonate production
The list may be exhaustive but questions have been repeatedly asked on etiology of peptic ulcers.
Category:
Surgery
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now