Which is antigen presenting cell in the epidermis that is required for the induction of allergic contact dermatitis is:
Correct Answer: Langerhans cells
Description: Langerhans' cell is a specialized antigen-presenting cell that help in antigen recognition and activation T cell mediated immune response. Functions - phagocytosis, antigen processing, antigen presentation, interaction with lymphocytes. Release IL-1 Langerhans cells are derived from mesoderm Langerhans cells are present in stratum spinosum Birbeck granules - rod or racquet shaped - contain Langerin Langerhans' cell decrease in (PSC) Psoriasis Sarcoidosis Contact dermatitis Langerhans' cell increase in - Langerhans Cell Histiocytosis
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