The therapeutic efficacy of antihypeensive drug is blunted by NSAIDs because they:
Correct Answer: Decrease the synthesis of vascular prostacyclin
Description: Ans. is 'd' i.e., Decrease the synthesis of vascular prostacyclin o NSA IDs blunt the antihypeensive effect of diuretics. o Loop diuretics act paly (intrarenal hemodynamics) by increasing the synthesis of prostaglandins by stimulation of COX o Prostaglandins (especially PGE2 and PGI2) cause renal vasodilation, natriuresis and increased water clearance due to inhibition of the ADH action. o NSAIDs inhibit the synthesis of prostaglandins by inhibiting COX. Therefore, NSAIDs blunt the diuretic effect of loop diuretics.
Category:
Pharmacology
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