A characteristic pathological feature of Parkinson’s disease is presence of –
Correct Answer: Lewy bodies
Description: Pathologic Examination in Parkinson shows :
Gross / Macroscopically: Pallor of the substantia nigra and locus coeruleus
Microscopic Examination :
1. Loss of catecholaminergic neurons in these regions + gliosis
2. Lewy bodies.
Lewy bodies: are inclusion bodies found within neurons in Parkinson's disease.
Lewy bodies are single or multiple, intra-cytoplasmic, eosinophilic, round and elongated inclusions that often have a dense core surrounded by a pale halo.
Ultrastructurally: These are composed of fine filaments, densely packed in the core but loose at the rim.
Category:
Pathology
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