In internal injury in body leukocyte is recruited by ?
Correct Answer: IL 1
Description: Ans. is 'a' i.e., IL 1Internal injury in the cells of the body is recognized by cy_tosolic receptors that identify a diverse set of molecules that are liberated or altered as a consequence of cell damage.These molecules includeUric acid (a product of DNA breakdown),ATP (released from damaged mitochondria), reduced intracellular K+ concentrations (reflecting loss of ions because of plasma membrane injury),DNA when it is released into the cytoplasm and not sequestered in nucleiThese receptors activate a multiprotein cytosolic complex called the inflammasome, which induces the production of the cytokine interleukin-1 (IL-1).IL-1 recruits leukocytes and thus induces inflanunation.
Category:
Pathology
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