Which of the following is not conveed into an active metabolite?
Correct Answer: Lisinopril
Description: prodrugs are conveed into active metabolites all ACE inhibitors except captopril and lisinopril are prodrugs lisinopril: It is the lysine derivative of enalaprilat: does not require hydrolysis to become an active ACE inhibitor. Fluoxetine has an active demethylated metabolite Diazepam has an active metabolite Desmethyl-diazepam, oxazepam Cyclophosphamide have active metabolite Aldophosphamide, .phosphorarmide mustard, acrolein Ref ;KD Tripathi pharmacology 7th edition (page no; 503,461,22,23)
Category:
Pharmacology
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