Medical MCQ - A PATIENT ON LITHIUM THERAPY DEVELOPED HTN,HE WAS STAED ON THIAZIDES FOR HYPEENSION .AFTER FEW DAYS HE DEVELOPED COARSE TREMORS AND OTHER SYMPTOMS SUGGESTIVE OF LITHIUM TOXICITY .EXPLAIN THE LIKELY MECHANISM ::

A PATIENT ON LITHIUM THERAPY DEVELOPED HTN,HE WAS STAED ON THIAZIDES FOR HYPEENSION .AFTER FEW DAYS HE DEVELOPED COARSE TREMORS AND OTHER SYMPTOMS SUGGESTIVE OF LITHIUM TOXICITY .EXPLAIN THE LIKELY MECHANISM ::

THIAZIDE INHIBIT METABOLISM OF LITHIUM

THIAZIDE AXT AS AN ADD ON DRUG TO LITHIUM

THIAZIDE INCREASE THE TUBULAR REABSORPTION OF Li

THIAZIDE CAUSE LOSS OF WATER THERBY INCREASES Li LEVELS

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THIAZIDE INCREASE THE TUBULAR REABSORPTION OF Li

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DRUG INTERACTION OF LITHIUM : THIAZIDE DIURETICS INCREASE THE LITHIUM TOXICITY LOOP DIURETICS AND K+ SPARING DIURETICS -- NORMAL OR INC. LITHIUM OSMOTIC DIURETICS AND CARBONIC ANHYDRASE INHIBITORS WILL DECREASE THE LITHIUM LEVELS. REF : KD TRIPATHI 8TH ED

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