Which intravenous anesthetic agent has local anaesthetic the propeies-
Correct Answer: Ketamine
Description: Ketamine interact with voltage - gated sodium channels sharing binding site with local anesthetic. Local Anesthetics can also bind to other receptors like voltage -gated potassium channels and nicotinic acetylcholine receptors, it is widely accepted that anesthesia and analgesia is by interaction with Na+ channel. Other drugs - ketamine, Tricyclic antidepressant and Anticonvulsant has also effect on Na+ channel.
Category:
Anaesthesia
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