Methotrexate (an older cancer treatment medication) can be used as first-line therapy for rheumatologic and psoriatic diseases. One of the side effects of methotrexate usage mimics which one of the following vitamin deficiencies?
Correct Answer: Folate (B9)
Description: Methotrexate targets and inhibits FH2 reductase, which catalyzes the reduction of FH2 to FH4 . Thus, in the presence of methotrexate, FH4 cannot be regenerated, and the body becomes functionally folate deficient. Methotrexate does not interfere with the absorption or reactions of the other B vitamins listed as potential answers.
Category:
Biochemistry
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