All of the following are true regarding G6PD deficiency except: March 2010
Correct Answer: Females are commonly affected
Description: Ans. B: Females are commonly affected G6PD deficiency is a recessive X-linked trait, placing males at higher risk for symptomatic disease. It is most common in Black patients or African descent (Class III). It has a protective effect against plasmodium falciparum malaria. Pathophysiology Glucose-6-phosphate dehydrogenase (G6PD) - Catalyzes NADP to NADPH (pentose phosphate path) - NADPH prevents oxidative damage to cells - RBCs depend on G6PD for sole pathway to NADPH - RBCs are most susceptible to insufficient G6PD Oxidative stress results in acute Hemolytic Anemia Drug-induced Hemolysis affects older cells -Younger cells have adequate enzyme levels to survive G6PD mutations occur on distal long arm of C chromosome Causes Medications in G6PD Deficiency-Onset within 72 hours of intake - Chloroquine and primaquine - Sulfonamides - Nitrofurantoins Infection (most common cause) - Salmonella - Eschirichia coli - Beta-hemolytic Streptococcus
Category:
Pathology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now