Mechanism of action of dantroline is ?
Correct Answer: Binds to ryanodine receptors to block release of Ca++
Description: Ans. is 'b' i.e., Binds to ryanodine receptors to block release of Ca++ o Dantrolone acts on Ryanodine receptors (RyR) Calcium channels in sarcoplasmic reticulum of skeletal muscles and prevents their depolarization triggered opening --> no release of intracellular Ca-+2 --> No excitation contraction coupling --> No contraction.
Category:
Pharmacology
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