60 yrs old male with bony abnormality at upper tibia associated with sensorineural hearing loss. On laboratory examination serum alkaline phosphatase levels are (440mU/I) elevated and serum Ca ++ and PO4- are normal, Skeletal survey shows ivory vertebrae and cotton wool spots in x-ray skull.Diagnosis is –

Correct Answer: Paget's disease
Description: Increased serum alkaline phosphatase Normal calcium and phosphate Bony lesions in skull and vertebrae Sensorineural hearing loss Amongst the given option, these feature can occur only in Paget's disease.
Category: Orthopaedics
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