A 45 year old patient presented with neurological deficits and seizures. Imaging showed a lesion in the temporal lobe. Biopsy was taken from the lesion and neural tissue sent for histological examination (microscopy shown below). Based on the characteristic histological features, what is the most likely diagnosis?
Correct Answer: Oligodendroglioma
Description: Oligodendroglioma: The tumors are composed of bwith spherical nuclei containing finely granular chromatin (similar to normal oligodendrocytes) surrounded by a clear halo of vacuolated cytoplasm giving a 'fried egg' appearance. The tumor typically contains a delicate network of anastomosing capillaries ('chicken-wire' capillaries). Perinuclear satellitosis is a feature of oligodendroglioma. Most commonly presented in the fouh and fifth decades . The lesion is mostly found in the cerebral hemispheres (mainly in temporal or frontal lobes). Image on the left showing perinuclear halos giving rise to a 'fried-egg' appearance. Image on the right showing Perineuronal satellitosis.
Category:
Pathology
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