Which of the following are chemokines?
Correct Answer: IL-8
Description: Their name is derived from their ability to induce directed chemotaxis in nearby responsive cells; they are chemotactic cytokines
C-X-C OR ALPHA CHEMOKINE
a. CXC chemokines specifically induce the migration of neutrophils
b. Secreted by activated macrophage t endothelial cell and other cell
c. Includes IL-8
C-C OR BETA CHEMOKINE:
a. induce chemotaxis of monocytes, eosinophils, lymphocytes but not neutrophils
b. Includes
I. Monocyte chemoattractant protein ( MCP-1)
II. Eotaxin
III. Macrophage inflammatory protein ( MIP)
IV. RANTES
C-CHEMOKINE OR GAMMA CHEMOKINES
a. Relatively specific for lymphocyte
b. Include lymphotactin
CXC CHEMOKINE
a. Two forms
I. Cell surface-bound
II. Soluble
b. Include fractalkine
Category:
Pathology
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