Resistance to zidovudne develops due to:

A. Mutation at reverse transcriptase

B. Increased efflux of the drug from inside the cell

C. Increased metabolism of the drug

D. Decreased zidovudine 5 triphosphate formation

Correct Answer: Mutation at reverse transcriptase

Description: Zidovudine;It is a thymidine analogue (azidothymidine, AZT), the prototype NI. After phosphorylation in the host cell-zidovudine triphosphate selectively inhibits viral reverse transcriptase (RNA-dependent DNA polymerase) in preference to cellular DNA polymerase Resistance to AZT occurs by point mutations which alter reverse transcriptase enzyme. ESSENTIALS OF MEDICAL PHARMACOLOGY K.D.TRIPATHI SIXTH EDITION PAGE NO:770

Category: Pharmacology

Share:

← Previous MCQ

Next MCQ →

Get More

Subject Mock Tests

Practice with over 200,000 questions from various medical subjects and improve your knowledge.

Attempt a mock test now

Mock Exam

Take an exam with 100 random questions selected from all subjects to test your knowledge.

Coming Soon

Get More

Subject Mock Tests

Try practicing mock tests with over 200,000 questions from various medical subjects.

Attempt a mock test now

Mock Exam

Attempt an exam of 100 questions randomly chosen from all subjects.

Coming Soon