Antiplatelet drug acting via purinergic receptors, not largely impacted by CYP2C19 polymorphism is:
Correct Answer: Prasugrel
Description: Ref. KDT. Page. 629
Prasugrel is a prodrug , similar to Clopidogrel
Thienopyridine drug class
Irreversible antagonist of P2Y12 ADP receptors
Rapidly absorbed, completely activated & exerts more consistent platelet inhibition. No interaction with CYP2C19 polymorphism
Strong anti-platelet activity
Bleeding complications are more serious and frequent.
Contraindicated in patients with history of ischemic strokes and TIA’s
Category:
Unknown
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