Notch effect in embryogenesis is an example of which type of signalling?
Correct Answer: Paracrine
Description: One cell type produces the ligand, which then acts on adjacent target cells that express the appropriate receptor. The responding cells are in close proximity to the ligand-producing cell and are generally of a different type. Paracrine stimulation is common in connective tissue repair of healing wounds, in which a factor produced by one cell type (e.g., a macrophage) has a growth effect on adjacent cells (e.g., a fibroblast). It is also necessary for hepatocyte replication during liver regeneration and for Notch effects in embryonic development, wound healing, and renewing tissues. Ref: Robbins 8th edition, Chapter 3
Category:
Pathology
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